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KMID : 0613820090190060698
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Journal of Life Science
2009 Volume.19 No. 6 p.698 ~ p.704
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ACE Inhibitory Lignan Glycosides Isolated from Eucommia ulmoides Oliver
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Joo Ok-Soo
Nam Sang-Hae
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Abstract
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To evaluate a potential possibility of Eucommia ulmoides Oliver as a functional food, ACE (angiotensin converting enzyme) inhibitory activities of leaf, bark, stem and 4 compounds isolated from E. ulmoides were tested. The 4 compounds were isolated and purified by silica gel column chromatography, thin layer chromatography and reverse phase column chromatography. Compound I was pinoresinol-4,4’-di-O-β-D-glucoside (PG) and compound Ⅱ was dehydrodiconiferyl alcohol 4,γ’-di-O-β-D-glucopyranoside (DAG) originating from Eucommial Cortex. The highest amount of PG was present at raw and roasted bark as 135.13 ㎎% and 163.67 ㎎%, and the highest amount of DAG was present at raw and roasted leaf as 117.93 ㎎% and 133.93 ㎎% respectively. In an ACE inhibition test, 10 ㎎/㎖ of roasted leaf, raw and roasted bark extracts of E. ulmoides Oliver were 77.49%, 75.72% and 75.36% respectively, and 10㎎/㎖ of PG and DAG were shown to be 78.51 and 81.20% respectively. IC?? values of PG and DAG were 0.6±0.2 and 0.5±0.2 ㎎/㎖ respectively.
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KEYWORD
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Eucommia ulmoides Oliver, antihypertension, angiotensin converting enzyme (ACE), pinoresinol-4, 4’-di-O-β-D-glucoside (PG), dehydrodiconiferyl alcohol 4, γ’-di-O-β-Dglucopyranoside (DAG)
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